Liver cancer survival time tripled by virus

The virus used in the vaccine that helped eradicate smallpox is now working its magic on liver cancer. A genetically engineered version of the vaccinia virus has trebled the average survival time of people with a severe form of liver cancer, with only mild, flu-like side effects.

Thirty people with hepatocellular carcinoma received three doses of the modified virus – code-named JX-594 – directly into their liver tumour over one month. Half the volunteers received a low dose of the virus, the other half a high dose. Members of the low and high-dose groups subsequently survived for, on average, 6.7 and 14.1 months respectively. By contrast, trials several years ago showed that sorafenib, the best existing medication for this cancer, prolonged life by only three months.

Two of the patients on the highest viral dose were still alive more than two years after the treatment. "It's a very substantial survival benefit," says Laurent Fischer, president of Jennerex, the company in San Francisco developing the treatment under the trade name Pexa-Vec.

Besides shrinking the primary tumour, the virus was able to spread to and shrink any secondary tumours outside the liver. "Some tumours disappeared completely, and most showed partial destruction on MRI scans," says David Kirn, head of the study at Jennerex. Moreover, the destruction was equally dramatic in the primary and secondary tumours.

"This clinical trial is an exciting step forward to help find a new way of treating cancers," says Alan Melcher of the University of Leeds, UK, who was not involved in the study. "It helps demonstrate the cancer-fighting potential of viruses, which have relatively few side effects compared with traditional chemo or radiotherapy," he says. "If it proves effective in larger trials, it could be available to patients within five years."

The fact that the virus appears able to spread to secondary tumours suggests that simply injecting the virus into the bloodstream may be effective. A trial to compare this treatment with injecting the virus directly into a tumour is under way.

Targeted at cancer

The virus has had a gene coding for an enzyme called thymidine kinase snipped out. The enzyme enables the virus to recognise and infect dividing cells. By removing the gene, the virus's developers have reduced the likelihood of healthy dividing cells being infected.

Instead, the virus exclusively attacks cancerous tissue, by targeting two genes that have increased activity in tumour cells. One genes is associated with an epidermal growth factor receptor, which stimulates the cancer to grow. The other is associated with a vascular endothelial growth factor, which enables the cancer to recruit its own blood supply. The virus reduces the activity of both genes, causing the infected cancer cell to wither and die.

What's more, the virus carries extra genes to prod the body's own immune system into action against the cancer. One produces granulocyte colony stimulating factor, a protein that encourages production of extra white blood cells at sites of infection. The other produces a protein not naturally found in humans, called Lac-Z, that earmarks infected cells for destruction.

Fischer says that to date, more than 200 people have received the virus, which has also shown promise against other types of cancer, including those of the kidney and skin. But he warns that not everyone sees a benefit. "We know why patients respond, but not why they don't," he says.

Journal reference: Nature Medicine, DOI: 10.1038/nm.3089

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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"Babel" by Mumford&Sons wins best album Grammy

LOS ANGELES: "Babel" by British folk rockers Mumford&Sons won the coveted Album of the Year award at the 55th Grammy Awards on Sunday.

They beat "El Camino" by The Black Keys, "Some Nights" by fun., "Channel Orange" by R&B singer Frank Ocean and "Blunderbuss" by Jack White, at the climax of the music industry's biggest awards show.

The top prize largely came as a surprise after Mumford&Sons lost out in other key categories, although they took the Best Long Form Music Video for "Big Easy Express."

Mumford&Sons had been nominated for Grammys the previous two years, including for Record of the Year in 2012, but had not taken home a prize until Sunday.

"Somebody That I Used to Know" by Gotye featuring Kimbra won the coveted Record of the Year award.

The song beat "Lonely Boy" by The Black Keys, "Stronger (What Doesn't Kill You)" by Kelly Clarkson, "We Are Young" by fun., "Thinkin Bout You" by Frank Ocean and "We Are Never Ever Getting Back Together" by Taylor Swift.

Belgian-Australian Gotye had already won the 2013 best pop duo/group performance and best alternative music album for "Making Mirrors," his third studio album.

He was presented with the best record award by pop icon Prince. "We're pretty huge fans, we've grown up listening to his music...that's pretty cool," he said, speaking backstage.

"We didn't expect to win... There are so many amazing artists and pieces of music... it's a little bit flabbergasting," he added.

"Somebody That I Used to Know" has been a hit in several countries.

Indie pop band fun. won the best new artist prize at the awards, their second win in the top four categories.

The New York band had already taken the Best Song Grammy for "We Are Young" and are also shortlisted in Album of the Year category, although they fell short of a landmark clean sweep when Record of the Year went to Gotye.

For the best new artist award, fun. beat out high-selling R&B singer Frank Ocean, Americana rockers Alabama Shakes, folk band The Lumineers and country singer Hunter Hayes.

The members of fun. were joined at the Grammy ceremony by Lena Dunham, creator of the critically acclaimed dark comedy "Girls," who is said to be dating the band's guitarist Jack Antonoff.

Their beaten rivals in the best song category were Ed Sheeran for "The A Team," Miguel for "Adorn," Carly Rae Jepsen for "Call Me Maybe" and the songwriters of Kelly Clarkson's "Stronger (What Doesn't Kill You)."

The band topped Grammy nominations announced in December.

If they were to win all four of the major categories, it would mark the first such achievement in more than 30 years, according to The New York Times.

British songstress Adele won the Grammy for best pop solo performance, the first award handed out during the main event.

She also gave a typically straight-talking answer when asked how she is feeling about the Oscars later this month, where she is nominated for best song for the theme tune to Bond movie "Skyfall," admitting she was nervous.

The 24-year-old singer, who swept the board with six Grammys at last year's awards show, took the pop performance prize for a live rendition of her hit "Set Fire to the Rain."

"My good luck charm, J-Lo," she said as she accepted the award from Jennifer Lopez and Pitbull. "This is amazing. I wanted to come and be part of the night. I loved it last year, obviously," she added.

Last year she won best song, best record, best album for her breakthrough "21," best short video, best pop album and best pop artist, winning all six categories in which she was nominated.

Speaking backstage after accepting her award Sunday, Adele said it was less stressful this year than last, even though she is now a mother, having given birth in October.

"I've been up since 6:00 am so I'm quite tired," she told reporters, but added that, as a new mother "it's nice, I haven't been as stressed out... you have to prioritize what you stress about and worry about."

Here are the winners of the main categories at the 55th Grammy Awards:

Album of the Year: "Babel" - Mumford&Sons

Record of the Year: "Somebody That I Used To Know" - Gotye featuring Kimbra

Song of the Year: "We Are Young" - fun.

Best New Artist: fun.

Best Rock Song: "Lonely Boy" - The Black Keys

Best Rock Album: "El Camino" - The Black Keys

Best R&B Song: "Adorn" - Miguel

Best R&B Album: "Black Radio" - Robert Glasper Experiment

Best R&B Performance: "Climax" - Usher

Best Traditional R&B Performance: "Love on Top" - Beyonce

Best Urban Contemporary Album: "Channel Orange" - Frank Ocean

Best Pop Performance, Solo: "Set Fire to the Rain (live)" - Adele

Best Pop Performance, Duo or Group: "Somebody That I Used to Know" - Gotye featuring Kimbra

Best Pop Vocal Album: "Stronger" - Kelly Clarkson

Best Traditional Pop Vocal Album: "Kisses On The Bottom" - Paul McCartney

Best Rap Song: "Ni**as In Paris" - Jay-Z & Kanye West

Best Rap Album: "Take Care" - Drake

Best World Music Album: "The Living Room Sessions Part 1" - Ravi Shankar

Best Alternative Music Album: "Making Mirrors" - Gotye

Best Orchestral Performance: "Adams: Harmonielehre & Short Ride In A Fast Machine" - San Francisco Symphony

Best Opera Recording: "Wagner: Der Ring Des Nibelungen" - The Metropolitan Opera Orchestra, The Metropolitan Opera Chorus

Best Jazz Instrumental Album: "Unity Band" - Pat Metheny Unity Band

Best Country Song: "Blown Away" - Carrie Underwood

Best Country Album: "Uncaged" - Zac Brown Band

Best Hard Rock/Metal Performance: "Love Bites (So Do I)" - Halestorm

Best New Age Album: "Echoes of Love" - Omar Akram

- AFP/ir

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Almost famous: See celebs' early roles

By Henry Hanks, CNN

updated 5:05 PM EST, Thu February 7, 2013

Stars who started out like GoDaddy's geek

Jesse Heiman

Sylvester Stallone

John Travolta

Keanu Reeves

Courtney Cox

Matt LeBlanc

Tina Fey

Rainn Wilson

Megan Fox

Dean Winters

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New Englanders slowly recover from weekend blizzard

NEWPORT, R.I. Travel eased and life slowly returned to normal for most New Englanders after a massive blizzard, but many remained without power in cold and darkened homes and a forecast of rain brought a new worry: Weight piling up dangerously on roofs already burdened by heavy snow.

61 Photos

Powerful blizzard descends on Northeast

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Northeast sees record snow fall

The storm that slammed into the region with up to 3 feet of snow was blamed for at least 14 deaths in the Northeast and Canada, and brought some of the highest accumulations ever recorded. Still, coastal areas were largely spared catastrophic damage despite being lashed by strong waves and hurricane-force wind gusts at the height of the storm.

President Barack Obama declared a state of emergency for Connecticut, allowing federal aid to be used in recovery, and utilities in some hard-hit New England states predicted that the storm could leave some customers in the dark for days.

CBS News correspondent Miguel Bojorquez reports that Hamden, Conn., about 80 miles from New York City, experienced the deepest snow: 40 inches. The blizzard had dumped five inches of snow per hour.

Hundreds of people, their homes without heat or electricity, were forced to take refuge in emergency shelters set up in schools or other places.

"For all the complaining everyone does, people really came through," said Rich Dinsmore, 65, of Newport, R.I., who was staying at a Red Cross shelter set up in a middle school in Middletown after the power went out in his home on Friday.

Dinsmore, who has emphysema, was first brought by ambulance to a hospital after the medical equipment he relies on failed when the power went out and he had difficulty breathing.

"The police, the fire department, the state, the Red Cross, the volunteers, it really worked well," said the retired radio broadcaster and Army veteran.

Utility crews, some brought in from as far away as Georgia, Oklahoma and Quebec, raced to restore power to more than 300,000 customers -- down from 650,000 in eight states at the height of the storm. In hardest-hit Massachusetts, where some 234,000 customers remained without power on Sunday, officials said some of the outages might linger until Tuesday.

Driving bans were lifted and flights resumed at major airports in the region that had closed during the storm, though many flights were still canceled Sunday.

Boston recorded 24.9 inches of snow, making it the fifth-largest storm in the city since records were kept.

On eastern Long Island, which was slammed with as much as 30 inches of snow, hundreds of snowplows and other heavy equipment were sent in Sunday to clear ice- and drift-covered highways where hundreds of people and cars were abandoned during the height of the storm.

More than a third of all the state's snow-removal equipment was sent to the area, Gov. Andrew Cuomo said, including more than 400 plow trucks and more than 100 snow blowers, loaders and backhoes.

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Snow leaves Long Island Expressway commuters stranded

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Mass. town powerless after record snow storm

The National Weather Service was forecasting rain and warmer temperatures in the region on Monday -- which could begin melting some snow but also add considerable weight to snow already piled on roofs, posing the danger of collapse. Of greatest concern were flat or gently-sloped roofs and officials said people should try to clear them -- but only if they could do so safely.

"We don't recommend that people, unless they're young and experienced, go up on roofs," said Peter Judge, spokesman for the Massachusetts Emergency Management Agency.

Officials also continued to warn of carbon monoxide dangers in the wake of the storm.

In Boston, two people died Saturday after being overcome by carbon monoxide while sitting in running cars, including a teenager who went into the family car to stay warm while his father shoveled snow. The boy's name was not made public. In a third incident, two children were hospitalized but expected to recover.

A fire department spokesman said in each case, the tailpipes of the cars were clogged by snow.

Authorities also reminded homeowners to clear snow from heating vents to prevent carbon monoxide from seeping back into houses.

In Maine, the Penobscot County Sheriff's office said it recovered the body of a 75-year-old man who died after the pickup he was driving struck a tree and plunged into the Penobscot River during the storm. Investigators said Gerald Crommett apparently became disoriented while driving in the blinding snow.

Christopher Mahood, 23, of Germantown, N.Y., died after his tractor went off his driveway while he was plowing snow Friday night and rolled down a 15-foot embankment.

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Possible Dorner Sighting Leads to Store Evacuation

A Northridge, Calif., home improvement store was evacuated tonight because of a possible sighting of suspected cop-killer Christopher Dorner, just hours after police announced a $1 million reward for information leading to his arrest.

As helicopters hovered overhead and a command center was established, police searched the Lowe's store and eventually told shoppers they could leave, but could not take their cars out of the parking lot.

LAPD spokesman Gus Villanueva said the major response to the possible sighting was a precaution, but couldn't say whether Dorner was in the area.

The announcement of the $1 million reward today came as authorities in Big Bear, Calif., scaled back their search for Dorner, the disgruntled ex-cop who is suspected in three revenge killings.

"This is the largest local reward ever offered, to our knowledge," Los Angeles Police Chief Charlie Beck said at a news conference today. "This is an act of domestic terrorism. This is a man who has targeted those that we entrust to protect the public. His actions cannot go unanswered."

The money for the reward was pooled by businesses, government, local law enforcement leaders and individual donors, Beck said.

PHOTOS: Former LAPD Officer Suspected in Shootings

The reward comes on the fourth day of a manhunt for Dorner, who has left Southern California on edge after he allegedly went on a killing spree last week to avenge his firing from the police force. Dorner outlined his grievances in a 6,000 word so-called "manifesto" and said he will keep killing until the truth is known about his case.

Irvine Police Department/AP Photo

Manhunt for Alleged Cop Killer Heads to California Mountains Watch Video

Christopher Dorner Search: Officials Search for Ex-officer in the Mountains Watch Video

Dorner's threats have prompted the LAPD to provide more than 50 law enforcement families with security and surveillance detail, Beck said.

Authorities are chasing leads, however they declined to say where in order to not impede the investigation.

Dorner's burned-out truck was found Thursday near Big Bear Lake, a popular skiing destination located 80 miles northeast of Los Angeles.

Investigators found two AR-15 assault rifles in the burned-out truck Dorner abandoned, sources told ABC News.

The truck had a broken axle, which may be the reason he decided to set fire to it, the police sources said.

Full Coverage: Christopher Jordan Dorner

Officers have spent the past couple of days going door-to-door and searching vacant cabins. The manhunt was scaled back to 25 officers and one helicopter in the resort town today, according to the San Bernadino Sheriff's Office.

On Saturday, Beck announced he would reopen the investigation into Dorner's firing but said the decision was not made to "appease" the fugitive ex-cop.

"I feel we need to also publicly address Dorner's allegations regarding his termination of employment, and to do so I have directed our Professionals Standards Bureau and my Special Assistant for Constitutional Policing to completely review the Dorner complaint of 2007; To include a re-examination of all evidence and a re-interview of witnesses," Beck said. "We will also investigate any allegations made in his manifesto which were not included in his original complaint."

Dorner is suspected of killing Monica Quan and her fiancé Keith Lawrence last Sunday in their car in the parking lot of their Irvine, Calif., condominium complex. Both were struck with multiple gunshot wounds.

Quan's father, Randal Quan, was a retired captain with the LAPD and attorney who represented Dorner before a police review board that led to Dorner's dismissal from the force in 2008.

On Wednesday, after Dorner was identified as a suspect in the double murder, police believe he ambushed two Riverside police officers, killing one and wounding the other.

The next day, Randal Quan reported he received a taunting call from a man claiming to be Dorner who told him that he "should have done a better job of protecting his daughter," according to court documents documents.

Anyone with information leading to the arrest of Christopher Dorner is asked to call the LAPD task force at 213-486-6860.

ABC News' Dean Schabner, Jack Date, Pierre Thomas, Jason Ryan and Clayton Sandell and The Associated Press contributed to this report.

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Sooty ships may be geoengineering by accident

GEOENGINEERING is being tested - albeit inadvertently - in the north Pacific. Soot from oil-burning ships is dumping about 1000 tonnes of soluble iron per year across 6 million square kilometres of ocean, new research has revealed.

Fertilising the world's oceans with iron has been controversially proposed as a way of sucking carbon dioxide out of the atmosphere to curb global warming. Some geoengineers claim releasing iron into the sea will stimulate plankton blooms, which absorb carbon, but ocean processes are complex and difficult to monitor in tests.

"Experiments suggest you change the population of algae, causing a shift from fish-dominated to jellyfish-dominated ecosystems," says Alex Baker of the University of East Anglia, UK. Such concerns led the UN Convention on Biological Diversity (CBD) to impose a moratorium on geoengineering experiments in 2010.

The annual ship deposition is much larger, if less concentrated, than the iron released in field tests carried out before the moratorium was in place. Yet because ship emissions are not intended to alter ocean chemistry, they do not violate the moratorium, says Jim Thomas of the ETC Group, a think tank that consults for the CBD. "If you intentionally drove oil-burning ships back and forth as a geoengineering experiment, that would contravene it."

The new study, by Akinori Ito of the Japan Agency for Marine-Earth Science and Technology, is the first to quantify how shipping deposits iron in parts of the ocean normally deficient in it. Earlier models had assumed that only 1 to 2 per cent of the iron contained in aerosols, including shipping emissions, is soluble in seawater, so the remaining 98 to 99 percent would sink to the bottom without affecting ocean life. But Ito found that up to 80 per cent of the iron in shipping soot is soluble (Global Biogeochemical Cycles, doi.org/kdj). As this soot rapidly falls to the sea surface, it is likely to be fertilising the oceans.

In the high-latitude north Pacific - a region that is naturally iron-poor and therefore likely to be most affected by human deposits - ship emissions now account for 70 per cent of soluble iron from human activity, with the burning of biomass and coal accounting for the rest. Shipping's share will rise as traffic continues to grow and regulations restrict coal and biomass emissions.

Can we learn anything from this unintentional experiment? Baker thinks not. "The process isn't scientifically useful," he says, because the uncontrolled nature of the iron makes it difficult to draw meaningful comparisons.

The depositions are unlikely to be harmful at current levels, he says, but "given the uncertainties, I just don't know how much these iron emissions would have to increase before there was demonstrable harm to an ecosystem, or benefit in terms of carbon uptake, for that matter".

This article appeared in print under the headline "Ships inadvertently fertilise the oceans"

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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Year of the Snake welcomes first baby

SINGAPORE: The Chinese Year of the Water Snake welcomed its first baby in Singapore at the stroke of midnight Saturday.

The 2.78-kilogramme bundle of joy is the first born to proud parents Koh Su Ming and Zhang Jing Jing.

The baby boy made his appearance a week earlier than expected.

An exhausted Madam Zhang said the labour lasted for 10 hours.

As the first child born in the Year of the Snake, the yet unnamed baby receives a cash gift in the form of an education endowment plan, among other things.

Mr Koh, the baby's father, said: "We feel very blessed that we have so many parties showering us with love and so many gifts, we feel very thankful."

- CNA/al

Read More..

Almost famous: See celebs' early roles

By Henry Hanks, CNN

updated 5:05 PM EST, Thu February 7, 2013

Stars who started out like GoDaddy's geek

Jesse Heiman

Sylvester Stallone

John Travolta

Keanu Reeves

Courtney Cox

Matt LeBlanc

Tina Fey

Rainn Wilson

Megan Fox

Dean Winters

Read More..

New Yorkers tell of hours stranded on snowy roads

FARMINGVILLE, N.Y. Stranded for hours on a snow-covered road, Priscilla Arena prayed, took out a sheet of loose-leaf paper and wrote what she thought might be her last words to her husband and children.

She told her 9 1/2-year-old daughter, Sophia, she was "picture-perfect beautiful." And she advised her 5 ?-year-old son, John: "Remember all the things that mommy taught you. Never say you hate someone you love. Take pride in the things you do, especially your family. ... Don't get angry at the small things; it's a waste of precious time and energy. Realize that all people are different, but most people are good. "

"My love will never die — remember, always," she added.

Arena, who was rescued in an Army canvas truck after about 12 hours, was one of hundreds of drivers who spent a fearful, chilly night stuck on highways in a blizzard that plastered New York's Long Island with more than 30 inches of snow, its ferocity taking many by surprise despite warnings to stay off the roads.

Even plows were mired in the snow or blocked by stuck cars, so emergency workers had to resort to snowmobiles to try to reach motorists. Four-wheel-drive vehicles, tractor-trailers and a couple of ambulances could be seen stranded along the roadway and ramps of the Long Island Expressway. Stuck drivers peeked out from time to time, running their cars intermittently to warm up as they waited for help.

With many still stranded hours after the snow stopped, Gov. Andrew Cuomo urged other communities to send plows to help dig out in eastern Long Island, which took the state's hardest hit by far in the massive Northeast storm.

In Connecticut, where the storm dumped more than 3 feet of snow in some places, the National Guard rescued about 90 stranded motorists, taking a few to hospitals with hypothermia.

51 Photos

Powerful blizzard descends on Northeast

The scenes came almost exactly two years after a blizzard marooned at least 1,500 cars and buses on Chicago's iconic Lake Shore Drive, leaving hundreds of people shivering in their vehicles for as long as 12 hours and questioning why the city didn't close the crucial thoroughfare earlier.

Cuomo and other officials were similarly asked why they didn't act to shut down major highways in Long Island in advance of the storm, especially given the sprawling area's reputation for gridlock. The expressway is often called "the world's longest parking lot."

"The snow just swallowed them up. It came down so hard and so fast," explained Suffolk County Executive Steven Bellone.

"That's not an easy call," added Cuomo, who noted that people wanted to get home and that officials had warned them to take precautions because the worst of the snow could start by the evening rush hour. Flashing highway signs underscored the message ahead of time: "Heavy Snow Expected. Avoid PM Travel!"

"People need to act responsibly in these situations," Cuomo said.

But many workers didn't have the option of taking off early Friday, Arena noted. The 41-year-old sales account manager headed home from an optical supply business in Ronkonkoma around 4 p.m. She soon found her SUV stuck along a road in nearby Farmingville.

"Even though we would dig ourselves out and push forward, the snow kept piling, and therefore we all got stuck, all of us," she recalled later at Brookhaven Town Hall, where several dozen stranded motorists were taken after being rescued. Many others opted to stay with their cars.

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Getting travel back to normal after blizzard

Richard Ebbrecht left his Brooklyn chiropractic office around 3 p.m. for his home in Middle Island, about 60 miles away, calculating that he could make the drive home before the worst of the blizzard set in. He was wrong.

As the snow came rushing down faster than he'd foreseen, he got stuck six or seven times on the expressway and on other roads. Drivers began helping each other shovel and push, he said, but to no avail. He finally gave up and spent the night in his car on a local thoroughfare, only about two miles from his home.

"I could run my car and keep the heat on and listen to the radio a little bit," he said.

He walked home around at 8 a.m., leaving his car.

Late-shifters including Wayne Jingo had little choice but to risk it if they wanted to get home. By early afternoon, he'd been stuck in his pickup truck alongside the Long Island Expressway for nearly 12 hours.

He'd left his job around midnight as a postal worker at Kennedy Airport and headed home to Medford, about 50 miles east. He was at an exit in Ronkonkoma — almost home — around 1:45 a.m. when another driver came barreling at him westbound, the wrong way, he said. Jingo swerved to avoid the oncoming car, missed the exit and ended up stuck on the highway's grass shoulder.

He rocked the truck back and forth to try to free it, but it only sank down deeper into the snow and shredded one of his tires. He called 911. A police officer came by at 9:30 a.m. and said he would send a tow truck.

At 1 p.m. Saturday, Jingo was still waiting.

"I would have been fine if I didn't have to swerve," he said.

In Middle Island, a Wal-Mart remained unofficially open long past midnight to accommodate more than two dozen motorists who were stranded on nearby roads.

"We're here to mind the store, but we can't let people freeze out there," manager Jerry Greek told Newsday.

Officials weren't aware of any deaths among the stranded drivers, Cuomo said. Suffolk County police said no serious injuries had been reported among stuck motorists, but officers were still systematically checking stranded vehicles late Saturday afternoon.

While the expressway eventually opened Saturday, about 30 miles of the highway was to be closed again Sunday for snow removal.

Susan Cassara left her job at a Middle Island day care center around 6:30 p.m., after driving some of the children home because their parents couldn't get there to pick them up.

She got stuck on one road until about 2:30 a.m. Then a plow helped her get out — but she got stuck again, she said. Finally, an Army National Guardsman got to her on a snowmobile after 4 a.m.

"It was so cool. Strapped on, held on and came all the way here" to the makeshift shelter at the Brookhaven Town Hall, she said. "Something for my bucket list."

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LAPD Reopens Case of Suspected Cop-Killer's Firing

The Los Angeles Police Department announced today it will reopen the case of the firing of Christopher Dorner, but said the decision was not made to "appease" the fugitive former cop suspected of killing three people.

Dorner, a fired and disgruntled former Los Angeles police officer, said in the so-called "manifesto" he released that he was targeting LAPD officials and their families and will keep killing until the truth is known about his case.

"I have no doubt that the law enforcement community will bring to an end the reign of terror perpetrated on our region by Christopher Jordan Dorner and he will be held accountable for his evil actions," LAPD Chief Charlie Beck said in a statement released tonight.

He spoke of the "tremendous strides" the LAPD has made in regaining public trust after numerous scandals, but added: "I am aware of the ghosts of the LAPD's past and one of my biggest concerns is that they will be resurrected by Dorner's allegations of racism within the Department."

To do that, he said, full re-investigation of the case that led to Dorner's firing is necessary.

"I feel we need to also publicly address Dorner's allegations regarding his termination of employment, and to do so I have directed our Professionals Standards Bureau and my Special Assistant for Constitutional Policing to completely review the Dorner complaint of 2007; To include a re-examination of all evidence and a re-interview of witnesses," he said. "We will also investigate any allegations made in his manifesto which were not included in his original complaint.

Irvine Police Department/AP Photo

Christopher Dorner Search: Officials Search for Ex-officer in the Mountains Watch Video

Hundreds of Officers on Hunt for Alleged Cop Killer Watch Video

"I do this not to appease a murderer. I do it to reassure the public that their police department is transparent and fair in all the things we do."

PHOTOS: Former LAPD Officer Suspected in Shootings

As police searched for Dorner today in the San Bernardino Mountains, sources told ABC News that investigators found two AR-15 assault rifles in the burned-out truck Dorner abandoned.

The truck had a broken axle, which may be the reason he decided to set fire to it, the police sources said.

A man identifying himself as Dorner taunted the father of Monica Quan four days after the former LAPD officer allegedly killed her and just 11 hours after he allegedly killed a police officer in Riverside, Calif., according to court documents obtained by ABC News

A man claiming to be Dorner called Randall Quan and told him that that he "should have done a better job of protecting his daughter," according to the documents.

In his 6,000-word "manifesto," Dorner named Randal Quan, a retired LAPD captain and attorney who represented him before a police review board that led to Dorner's dismissal from the force.

"I never had an opportunity to have a family of my own, I'm terminating yours," Dorner wrote, and directed Quan and other officials to "[l]ook your wives/husbands and surviving children directly in the face and tell them the truth as to why your children are dead."

Monica Quan and her fiancé Keith Lawrence were gunned down last Sunday in their car in the parking of their Irvine, Calif., condominium complex. Both were struck with multiple gunshot wounds.

The call, according to court records, was traced to Vancouver, Wash., but law enforcement officials do not believe Dorner was there at the time at the call.

Dorner is believed to have made the call early Thursday afternoon, less than half a day after he is suspected of killing a police officer and wounding two others early that morning, sparking an unprecedented man hunt involving more than a thousand police officers and federal agents spanning hundreds of miles.

FULL COVERAGE: Christopher Jordan Dorner

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